One Active Site, Two Reactions: Crystal Structure Reveals How Rare Enzyme ApnO Defies Classification

Researchers at Ehime University used X‑ray crystallography to determine the atomic structure of the enzyme D‑apionate oxidoisomerase (ApnO), revealing a single active site that accommodates two distinct reactions by binding different metal ions—zinc or manganese in a tetrahedral geometry and manganese in an octahedral geometry—providing insight into its dual catalytic capability.

Source: One Active Site, Two Reactions: Crystal Structure Reveals How Rare Enzyme ApnO Defies Classification — Bioengineer.org

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Topics: enzyme · crystalstructure · apno · biotech · science